George J. Zanazzi

The paper identifies regionally distinct CD8+ resident memory T cells in the human CNS shaped by viral infections using single-cell RNA sequencing and T cell receptor analysis.

XpressO-Lung predicts spatial gene expression patterns in lung adenocarcinoma using histopathology images, validated against immunohistochemistry, showing strong concordance with known morphologic features.

X-SPATIO predicts and visualizes spatially resolved biomarker expression in TNBC by linking H&E morphology with spatial transcriptomic and proteomic data.

This study identifies CD39 expression on functional effector and tissue-resident memory CD8+ T cells, showing its role in memory differentiation and function, distinct from its role in T cell exhaustion.

This study shows that male and female 3xTg-AD mice have different disease trajectories, with males showing more inflammation and females more neuropathology, mirrored in human Alzheimer's patients.

iSCORED enables rapid, unbiased CNV detection and methylation classification in brain tumors using Nanopore sequencing, achieving 100% concordance with standard methods.