Human endogenous retrovirus K (HERV-K) envelope structures in pre- and post-fusion by Cryo-EM
Jeremy Shek, Chen Sun, Elise M. Wilson, Fatemeh Moadab, Kathryn M. Hastie, Roshan R. Rajamanickam, Patrick J. Penalosa, Stephanie Harkins, Diptiben V. Parekh, Chitra Hariharan, Dawid S. Zyla, Cassandra Yu, Kelly C. L. Shaffer, Victoria I. Lewis, Rubén Díaz-Avalos, , Erica Ollmann Saphire
This study determines the pre- and post-fusion structures of HERV-K Env using cryo-EM, revealing unique features that may inform therapeutic strategies.
Science Advances · Aug 27, 2025Peer-reviewedBiochemistry