The paper determines cryo-EM structures of monoclonal antibodies bound to rabies virus glycoprotein, identifying new antigenic sites and their role in neutralization.

Cell Reports · Sep 17, 2026Peer-reviewedMicrobiology

A broadly-neutralizing antibody against Ebolavirus glycoprotein that potentiates the breadth and neutralization potency of other antibodies

Francesca R. Donnellan, Vamseedhar Rayaprolu, Pramila Rijal, Victoria O’Dowd, Amar D. Parvate, Heather Callaway, Chitra Hariharan, Dipti Parekh, Sean Hui, Kelly C. L. Shaffer, Rubén Díaz-Avalos, Kathryn M. Hastie, Lisa M. Schimanski, Helena Müller-Kräuter, Thomas Strecker, , Simon J. Draper

The paper identifies two broadly neutralizing antibodies against Ebolavirus glycoprotein and shows that one enhances the neutralization breadth and potency of other antibodies.

npj Viruses · May 7, 2026Peer-reviewedImmunology

Human endogenous retrovirus K (HERV-K) envelope structures in pre- and post-fusion by Cryo-EM

Jeremy Shek, Chen Sun, Elise M. Wilson, Fatemeh Moadab, Kathryn M. Hastie, Roshan R. Rajamanickam, Patrick J. Penalosa, Stephanie Harkins, Diptiben V. Parekh, Chitra Hariharan, Dawid S. Zyla, Cassandra Yu, Kelly C. L. Shaffer, Victoria I. Lewis, Rubén Díaz-Avalos, , Erica Ollmann Saphire

This study determines the pre- and post-fusion structures of HERV-K Env using cryo-EM, revealing unique features that may inform therapeutic strategies.

Science Advances · Aug 27, 2025Peer-reviewedBiochemistry