Single-cell analysis of an engineered organoid-based model of pancreatic cancer identifies hypoxia as a contributing factor in the determination of transcriptional subtypes
Natalie Landon‐Brace, Simon Latour, Brendan T. Innes, Michelle Nurse, Jose L. Cadavid, Ileana L. Co, Cassidy M Tan, Ferris Nowlan, Sibyl Drissler, Faiyaz Notta, Hartland Warren Jackson, Gary D. Bader, Alison P. McGuigan
This study uses single-cell transcriptomics to show that hypoxia in organoid models influences transcriptional subtypes in pancreatic cancer.
Scientific Reports · Jul 2, 2025Peer-reviewedCancer Biology