Sibyl Drissler

This study integrates spatial proteomics and genomics in PDAC to identify tumour-immune-stroma interactions and their genomic associations, showing multi-omics models improve patient survival prediction.

This study uses single-cell transcriptomics to show that hypoxia in organoid models influences transcriptional subtypes in pancreatic cancer.

The paper shows SOX9 acts as a pioneer factor that changes chromatin structure to drive endothelial-to-mesenchymal transition by activating mesenchymal enhancers and suppressing endothelial genes.

ConsensusDriver improves driver alteration prediction by combining multiple methods, increasing sensitivity by 20% across cancer types and individual patients.