Loss of Elp3 impairs the maturation tempo of brain ependymal cells
Sylvia Tielens, Camille Boutin, Sandra Huysseune, Nicolas Thelen, Manon Charlet‐Briart, Coralie Reyskens, Lea Oskera, Anaïs Boutsen, Susana Mateo Sánchez, Laurence Delacroix, Paul Labedan, Marc Thiry, Brigitte Malgrange, Alain Chariot, Fadel Tissir, , Laurent Nguyen
This study shows that loss of Elp3 in mouse forebrain causes microcephaly and hydrocephalus due to impaired ependymal cell maturation and cilia dysfunction.
bioRxiv · Jan 7, 2025 · PreprintNeuroscience