Laurent Nguyen

This study compares cortical interneuron migration across species, finding that human interneurons migrate slower and more dispersedly due to CCP1-dependent changes in microtubule dynamics.

The paper identifies MIRINE, a small ORF-encoded polypeptide that promotes neuronal differentiation in vertebrate brain development by regulating the balance between proliferation and maturation.

This study identifies Kif2C as a critical regulator of radial glial cell integrity, showing its role in preventing cortical malformations and linking its dysfunction to human neurodevelopmental disorders.

The paper identifies JUNB as a gene driving species-specific cortical features by comparing gene expression in mouse, human, and human cortical organoids.

This study uses human pluripotent stem cell-derived cerebellar organoids to investigate human cerebellar development and disease-related gene expression.

This study shows that Ccp1 depletion in hippocampal parvalbumin interneurons leads to hyperglutamylation, impaired axonal transport, and reduced perisomatic inhibition of pyramidal cells in the CA2 region.

This study shows that species-specific fatty acid oxidation rates influence temporal patterning of corticogenesis through protein acetylation dynamics in human and mouse cortical progenitors.

This study shows that loss of Elp3 in mouse forebrain causes microcephaly and hydrocephalus due to impaired ependymal cell maturation and cilia dysfunction.

This study shows SARS-CoV2 infects brain cells in cortical organoids, inducing reactive astrocyte states and inflammation.

The paper shows that CBP/EP300 acetylates and stabilizes HSF2, which is disrupted in Rubinstein-Taybi syndrome, leading to impaired heat shock response.

This study shows that oligodendrocyte precursor cells guide cortical interneuron migration through unidirectional contact repulsion during embryogenesis.

The paper analyzes single-cell RNA-Seq and ATAC-Seq data from native and iPSC-derived murine retina to identify regulatory toggles involved in differentiation.

This study shows that ATAT1-enriched vesicles are transported along axons to acetylate -tubulin, essential for proper vesicular transport.

The paper traces transcriptional trajectories of progenitors and neurons during mouse neocortex development, showing how molecular states from progenitors shape neuronal diversity.