Fadel Tissir

Competing Programs Shape Cortical Sensorimotor-Association Axis Development

The paper presents the MIND model, showing that competing induction and exclusion programs shape the sensorimotor-to-association axis in the neocortex across species.

Loss of Elp3 impairs the maturation tempo of brain ependymal cells

This study shows that loss of Elp3 in mouse forebrain causes microcephaly and hydrocephalus due to impaired ependymal cell maturation and cilia dysfunction.

Human mutations in high-confidence Tourette disorder genes affect sensorimotor behavior, reward learning, and striatal dopamine in mice

The paper generates mouse models with human mutations in TD genes, showing sensorimotor and reward learning phenotypes, dopamine changes, and sex-specific effects.

Early loss of Scribble affects cortical development and interhemispheric connectivity resulting in psychomotor dysregulation.

This study shows that Scrib deletion in mice causes cortical thinning, disrupted connectivity, and psychomotor deficits, linking Scrib to neurodevelopmental disorders.

DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

This study shows that DIAPH3 deficiency causes mitotic errors, neurogenesis defects, and brain dysfunction by disrupting microtubule dynamics and associated proteins.

Regeneration of spinal motor axons: Negative regulation by Celsr2 implicating Cdc42/Rac1 and JNK/c-Jun signaling

This study shows that Celsr2 negatively regulates motor axon regeneration in mice and humans, with its knockdown promoting axon regeneration and functional recovery.

Dystroglycan is a scaffold for extracellular axon guidance decisions

This study identifies Dystroglycan as an extracellular scaffold that coordinates axon guidance by interacting with environmental cues and the receptor Celsr3/Adgrc3.