Top2a-dependent neuronal regulation of social behavior and persistent rescue of social deficit through PRC2-mediated epigenetic reprogramming
Baixi He, Yuxuan Mao, Catherine Hong, Yijie Geng
This study shows that neuronal Top2a regulates social behavior in mice, and PRC2 inhibition can rescue social deficits through epigenetic reprogramming.
bioRxiv · Feb 26, 2026 · PreprintNeuroscience