The p53-p21 axis plays a central role in lymphatic homeostasis and disease
Rohan Mylavarapu, Molly R. Kulikauskas, Cathrin Dierkes, Nema Sobhani, Michelle Mangette, Jeffrey M. Finlon, Wanida Stevens, Farinaz Arbab, Neil F. Box, Mark A. Lovell, Ajit Muley, Carrie J. Shawber, Beth A. Jirón Tamburini, Friedemann Kiefer, Tamara Terzian
This study shows that overactive p53 in lymphatic endothelial cells causes lymphatic defects in mice and human tissues, and normalizing p53 restores lymphatic function.
bioRxiv · Mar 18, 2020 · PreprintDevelopmental Biology