Friedemann Kiefer

Super-Resolution Optical Sectioning Microscopy Visualizes Nanopores in the Plasma Membrane of Endothelial Cells in situ

The paper visualizes nanopores in endothelial cells in situ using a super-resolution microscope after staining with a fluorescent dye.

Specialized mesenteric lymphatic capillaries by-pass the mesenteric lymph node chain to transport peritoneal antigens directly into mediastinal lymph nodes.

The paper identifies a specialized mesenteric lymphatic capillary network that bypasses mesenteric lymph nodes to directly transport peritoneal antigens into mediastinal lymph nodes.

The blood vasculature instructs lymphatics patterning in a SOX7-dependent manner

This study identifies SOX7 as a transcription factor in blood vascular endothelial cells that represses Vegfc expression, influencing lymphatic vessel patterning in mice.

Direct specification of lymphatic endothelium from non-venous angioblasts

This study identifies a direct origin of lymphatic endothelial cells from non-venous angioblasts, challenging the prevailing view that they primarily derive from venous endothelium.

The p53-p21 axis plays a central role in lymphatic homeostasis and disease

This study shows that overactive p53 in lymphatic endothelial cells causes lymphatic defects in mice and human tissues, and normalizing p53 restores lymphatic function.