Scalable variant-to-function screens using prime editing perturb-seq
Joachim De Jonghe, Magdalena Armas, Catriona Jamieson, Jens Bager Christensen, James W. Opzoomer, Jake P. Taylor‐King
This paper introduces PEP-seq, a method linking genetic variants to transcriptomic states, and shows it can detect functional effects of eQTLs and nonsense-mediated decay.
bioRxiv · Oct 28, 2026 · PreprintGenomics