Jens Bager Christensen

This paper introduces PEP-seq, a method linking genetic variants to transcriptomic states, and shows it can detect functional effects of eQTLs and nonsense-mediated decay.

The paper identifies LRRC58 as a substrate adaptor in a Cul2 E3 ligase complex that regulates CDO1 degradation in response to cysteine availability, preventing ferroptosis and neurodevelopmental defects.

This study generates human appetite-regulating neurons and tanycytes from stem cells, identifying key progenitor markers and signaling mechanisms for hypothalamic subregion specification.

This study shows that reactive oxygen species (ROS) increase in the neonatal cerebellum after injury, and reducing ROS impairs regenerative processes.

The paper uses a microfluidic stem cell model to study early human neural patterning, identifying regional specification and fate determination during the epiblast stage.

The paper identifies FOXO1 as a key regulator of inhibitory neuron differentiation in mouse and human cerebellar progenitors, showing its conservation and regulation by WNT signaling.