Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewed
Prostate cancer-induced endothelial-to-osteoblast transition generates an immunosuppressive bone tumor microenvironment
Guoyu Yu, Paul Gettys Corn, Celia Sze Ling Mak…·Sue-Hwa Lin
This study identifies a prostate cancer-induced endothelial-to-osteoblast transition that creates an immunosuppressive bone tumor microenvironment, reducing the effectiveness of immune checkpoint therapy in bone metastatic castrate-resistant prostate cancer.
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