The Y chromosome gene KDM5D restrains CD8+ T cell antitumor immunity through TCR and cholesterol-exhaustion programs
Jiexi Li, Chi Yin Ching, Aviad Ben‐Shmuel, Paulino Tallón de Lara, Jingjing Liu, Shan Jiang, Chaohao Li, Ziyuan Zhang, William Huaiyang Wu, Max Slotnik, Xiaotian Wang, Raul Caballero Montes, Abhinav K. Jain, Nicholas J. Hornstein, Fadl A. Zeineddine, , Ronald Anthony DePinho
This study identifies KDM5D on the Y chromosome as a suppressor of CD8+ T cell antitumor immunity in males, linking it to TCR and cholesterol-exhaustion programs.
bioRxiv · Sep 1, 2026 · PreprintCancer Biology