Placental prostaglandin signaling disrupts barrier integrity and relays an acute inflammatory signal to the fetus.
Hana Horackova, Qiuying Zhao, Shakeela Faulkner, Jennifer Alvarez, Cenk Akiz, Yilin Liu, Josephine Crosthwait, Weiye Dai, Danielle Santoyo, Duke Pham-Chang, Nabeel Bhinderwala, Thea Tagliaferro, W. Dean Wallace, Saloni Walia, Jéléna Martinovic, , Alexandre Bonnin
Maternal immune activation disrupts placental vascular integrity through a COX2-dependent prostaglandin E2 pathway, compromising the placenta-blood barrier and relaying inflammatory signals to the fetus, identifying potential therapeutic targets for neuroprotection.
bioRxiv · Mar 12, 2026 · PreprintDevelopmental Biology