Yilin Liu

LncRNA-mediated organization of oncogenic chromatin state is a targetable vulnerability in leukemia

This study identifies PAN3-AS1 as an oncogenic lncRNA in AML, shows its role in chromatin organization, and demonstrates RNA-targeting LNP therapy to reduce leukemia burden.

Translation sustains productive Pol II elongation through maintenance of nuclear RNA surveillance

This study shows that ongoing translation sustains productive Pol II elongation and nuclear RNA homeostasis in mouse embryonic stem cells by maintaining RNA surveillance.

Placental prostaglandin signaling disrupts barrier integrity and relays an acute inflammatory signal to the fetus.

Maternal immune activation disrupts placental vascular integrity through a COX2-dependent prostaglandin E2 pathway, compromising the placenta-blood barrier and relaying inflammatory signals to the fetus, identifying potential therapeutic targets for neuroprotection.

GENETIC ANALYSIS OF ARABIDOPSIS AUTOPHAGY-RELATED 8 FAMILY PROTEINS REVEALS THEIR REDUNDANT AND REGULATORY ROLES IN PLANT AUTOPHAGY

This study uses CRISPR/Cas9 to knockout Arabidopsis ATG8 genes, revealing their redundant and regulatory roles in autophagy, with Clade I and II ATG8s showing overlapping functions and interactions with RABG3 proteins.