NeurosciencebioRxivPreprint
Pericyte Loss Reprogrammes Capillary Endothelium and Drives White Matter Injury in Small Vessel Disease
Dorota Stefancova, Audrey Chagnot, Michael D.E. Sewell…·Axel Montagne
1 citation
Author
Axel Montagne
British Heart FoundationORCID 0000-0001-5564-985XUnclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2021-2026 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 10 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship6 papers
Recent·Most cited
- PathologybioRxivPreprint
Abrupt Pericyte Loss Precedes Endothelial Activation in Cerebral Small Vessel Disease
Audrey Chagnot, Daniela Jaime García, Conor McQuaid…·Axel Montagne
This study identifies pericyte loss preceding endothelial activation in cerebral small vessel disease through single-vessel analysis of human brain tissue.
3 citations - Developmental BiologybioRxivPreprint
Placental prostaglandin signaling disrupts barrier integrity and relays an acute inflammatory signal to the fetus.
Hana Horackova, Qiuying Zhao, Shakeela Faulkner…·Alexandre Bonnin
Maternal immune activation disrupts placental vascular integrity through a COX2-dependent prostaglandin E2 pathway, compromising the placenta-blood barrier and relaying inflammatory signals to the fetus, identifying potential therapeutic targets for neuroprotection.
- NeurosciencebioRxivPreprint
APOE4 Genotype is Associated with Reduced Cortical VEGFR2 (KDR) Transcript Levels Independent of Endothelial Abundance: An AMP-AD RNA-seq Pilot Study
Krystal K. Laing, Axel Montagne
This study finds that APOE4 genotype is associated with reduced KDR transcript levels in cortical brain tissue, independent of endothelial cell abundance and neuropathological factors.
DOI 10.64898/2026.03.01.708815 - NeuroscienceNature CommunicationsPeer-reviewed
Single nuclear transcriptional signatures of dysfunctional brain vascular homeostasis in Alzheimer's disease
Stergios Tsartsalis, Hannah Sleven, Nurun Nahar Fancy…·Paul McMahan Matthews
The paper identifies transcriptional signatures in vascular cells from Alzheimer's disease brains, revealing dysregulated pathways linked to vascular dysfunction and immune activation.