Reduced efficacy of an anti-toxin vaccine from senescence-driven attenuation of toxin virulence
Xin Du, Ching-Wen Tseng, Elisabet Bjånes, Hunter Gage, Jaclyn Swan, Chih‐Ming Tsai, Irshad A. Hajam, Cesia Gonzalez, Brian J. Lin, Victor Nizet, George Y. Liu
This study shows that vaccine efficacy against Staphylococcus aureus alpha toxin decreases in aged mice due to reduced ADAM10 activity and myeloid cell dysfunction.
JCI Insight · Jun 8, 2026Peer-reviewedMicrobiology