Human iPSC-derived Committed Cardiac Progenitors Generate Cardiac Tissue Grafts in a Swine Ischemic Cardiomyopathy Model without Triggering Ventricular Arrhythmias
Amish N. Raval, Eric G. Schmuck, Vladislav Leonov, Sushmita Roy, Yukihiro Saito, Tianhua Zhou, Hee Jae Jang, Kaylee Wilker, James Conklin, Timothy A. Hacker, Chad H. Koonce, Meghan Boyer, Kristin Stack, Ellen Hebron, Scott K. Nagle, , Timothy J. Kamp
The paper demonstrates that hiPSC-derived cardiac progenitor cells injected into swine hearts after MI form grafts that improve stress-induced contractile reserve without causing arrhythmias.
Journal of the American Heart Association · Jul 25, 2026Peer-reviewedPathology