Timothy J. Kamp

This study identifies molecular pathways and regulatory programs associated with hPSC-CM maturation through multi-omic profiling during long-term culture.

The paper demonstrates that hiPSC-derived cardiac progenitor cells injected into swine hearts after MI form grafts that improve stress-induced contractile reserve without causing arrhythmias.

This study shows caveolae compartmentalize key proteins in SAN pacemaking, and their disruption leads to heart failure-related arrhythmias.

The paper develops a high-sensitivity protein extraction method for micropatterned hiPSC-CMs and shows they exhibit more mature molecular signatures compared to traditional cultures.

This paper identifies ICAM-1 as a novel hypoimmune target in human pluripotent stem cells, showing that its knock-out reduces immune cell adhesion and enhances graft survival.

The paper uses top-down proteomics to analyze MLC-1 and -2 isoform expression in human heart chambers, revealing chamber-specific patterns and a novel PTM.

This study compares the functional and molecular properties of engineered cardiac tissue constructs made from hiPSC-CMs purified by lactate or MACS methods, finding no significant differences.

This study shows that fibronectin promotes cardiac differentiation of human pluripotent stem cells, while laminins inhibit it, and identifies fibronectin's role in early differentiation through integrin signaling.