Spatial colocalization and combined survival benefit of natural killer and CD8 T cells despite profound MHC class I loss in non-small cell lung cancer
Remziye E. Wessel, Nardin Ageeb, Joseph Mounir Obeid, Ileana Soto Mauldin, Kate A. Goundry, Gabriel F. Hanson, Mahdin Hossain, Chad Lehman, Ryan D. Gentzler, Nolan A. Wages, Craig Lee Slingluff, Timothy N. J. Bullock, Sepideh Dolatshahi, Michael G. Brown
The paper examines the relationship between MHC-I expression, NK cell, and CD8 T cell infiltration in NSCLC, finding that higher infiltration correlates with improved survival despite MHC-I loss.
Journal for ImmunoTherapy of Cancer · Sep 1, 2024Peer-reviewedImmunology