Timothy N. J. Bullock

This study investigates the role of ST2 signaling in innate immune responses during kidney injury, finding that ST2 deletion reduces acute injury but worsens chronic injury.

The paper identifies benzimidazole compounds, including nocodazole, as NOD2 agonists with potential therapeutic benefits over existing MDP-based agonists.

This study identifies a stereoselective DGK inhibitor that enhances T cell activation and tumor cell cytotoxicity through proteasome-dependent degradation of DGK.

This study combines thermally ablative focused ultrasound with VEGFR2 blockade to enhance T cell-dependent anti-tumor immunity and synergize with checkpoint inhibition.

The paper examines the relationship between MHC-I expression, NK cell, and CD8 T cell infiltration in NSCLC, finding that higher infiltration correlates with improved survival despite MHC-I loss.

The paper identifies a female-specific chimeric RNA, UBA1-CDK16, and shows its role in myeloid differentiation and immune sexual dimorphism.