Tumor-initiating genetics and therapy drive divergent molecular evolution in IDH-mutant gliomas
Tamrin Chowdhury, C. Mircea S. Tesileanu, Emre Kocakavuk, Kevin C. Johnson, Joo-Ho Lee, Zeynep Erson-Omay, Chaewon Heo, Kenneth Aldape, Samirkumar B. Amin, Kevin J. Anderson, David M. Ashley, Jill S. Barnholtz‐Sloan, Daniel Jay Brat, Andrew R. Brodbelt, Ana Valeria Castro, , Roel G.W. Verhaak
This study identifies genetic changes in IDH-mutant gliomas that correlate with treatment response and tumor evolution using longitudinal genomic data from 206 patient samples.
bioRxiv · Jul 11, 2025 · PreprintCancer Biology