Author

Kevin C. Johnson

Yale UniversityORCID 0000-0003-0016-5158Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Research Focus:differential expression· 4 Assay:DNA methylation· 4 Research Focus:gene regulatory network inference· 2 Research Focus:clustering· 1 Research Focus:GWAS / association mapping· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Bart A. WestermaniD· 3 shared Frederick S. VarniD· 3 shared Mathilde C.M. KouwenhoveniD· 3 shared Michael WelleriD· 3 shared Mustafa KhasrawiD· 3 shared Pieter WesselingiD· 3 shared Pim J. FrenchiD· 3 shared Tobias WeißiD· 3 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Bart A. WestermanORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cancer BiologyCell Reports MedicinePeer-reviewedMar 1, 2026

TET CpG sequence context specific DNA demeth-ylation shapes progression of IDH-mutant gliomas

Youri Hoogstrate, Santoesha A. Ghisai, Levi van Hijfte…·Pim J. French

The paper identifies DNA methylation changes during IDH-mutant glioma progression, links them to TET enzyme activity, and develops a methylation-based grading system that outperforms WHO grading.

2 citationstop 3%

humanDNA methylation

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJul 11, 2025

Tumor-initiating genetics and therapy drive divergent molecular evolution in IDH-mutant gliomas

Tamrin Chowdhury, C. Mircea S. Tesileanu, Emre Kocakavuk…·Roel G.W. Verhaak

This study identifies genetic changes in IDH-mutant gliomas that correlate with treatment response and tumor evolution using longitudinal genomic data from 206 patient samples.

6 citations

humanwhole-genome sequencing

𝕏 PostBluesky

GenomicsCancer ResearchPeer-reviewedDec 20, 2023

The epigenetic evolution of gliomas is determined by their IDH1 mutation status and treatment regimen

Tathiane Maistro Malta, Thaís S. Sabedot, Natalia S. Morosini…·Peter S. LaViolette

This study analyzes the epigenetic evolution of IDH1-mutant and IDH1-wildtype gliomas under treatment, showing IDHmut tumors undergo epigenomic changes resembling IDHwt tumors, with implications for treatment strategies.

68 citationstop 1%

humanDNA methylation

𝕏 PostBluesky

GenomicsbioRxivPreprintJun 7, 2018

Genome-wide abundance of 5-hydroxymethylcytosine in breast tissue reveals unique function in dynamic gene regulation and carcinogenesis

Owen Michael Wilkins, Kevin C. Johnson, Eugene Andres Houseman…·Brock C. Christensen

The paper maps 5-hydroxymethylcytosine (5hmC) distribution in normal breast tissue and links it to gene regulation and cancer prevention.

1 citation

humanDNA methylation

𝕏 PostBluesky

GenomicsScientific ReportsPeer-reviewedSep 11, 2017

Deconvolution of DNA methylation identifies differentially methylated gene regions on 1p36 across breast cancer subtypes

Alexander Titus, Gregory P. Way, Kevin C. Johnson, Brock C. Christensen

25 citations

humanDNA methylation

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