Bart A. Westerman

EGFR upregulation drives signaling reactivation during EGFR inhibition in glioblastoma without broad kinome rewiring

This study shows that EGFR inhibition in glioblastoma does not lead to broad kinome rewiring but instead results in increased EGFR abundance and partial restoration of EGFR signaling.

TET CpG sequence context specific DNA demeth-ylation shapes progression of IDH-mutant gliomas

The paper identifies DNA methylation changes during IDH-mutant glioma progression, links them to TET enzyme activity, and develops a methylation-based grading system that outperforms WHO grading.

Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cycling

The paper analyzes multi-omics data from IDH-mutant astrocytomas to identify molecular markers of malignant progression linked to cell cycling and DNA methylation changes.

Tumor-initiating genetics and therapy drive divergent molecular evolution in IDH-mutant gliomas

This study identifies genetic changes in IDH-mutant gliomas that correlate with treatment response and tumor evolution using longitudinal genomic data from 206 patient samples.

The epigenetic evolution of gliomas is determined by their IDH1 mutation status and treatment regimen

This study analyzes the epigenetic evolution of IDH1-mutant and IDH1-wildtype gliomas under treatment, showing IDHmut tumors undergo epigenomic changes resembling IDHwt tumors, with implications for treatment strategies.