Fibrillarin modulates fetal hemoglobin silencing
Dongliang Wu, Qi‐Xiang Li, Sipei Qiu, Chan Guo, Feng Li, Wenbing Shangguan, Wenyang Li, Dongjun Yang, Xingjun Meng, Mengying Xing, Bing Chen, Lingdong Kong, David C.S. Huang, Quan Zhao
This study identifies fibrillarin as a repressor of the γ-globin gene and shows its dual role in activating BCL11A and repressing γ-globin expression, offering a potential therapeutic target for β-hemoglobinopathies.
bioRxiv · Jun 25, 2024 · PreprintMolecular Biology