Molecular BiologybioRxivPreprint
Fibrillarin modulates fetal hemoglobin silencing
Dongliang Wu, Qi‐Xiang Li, Sipei Qiu…·Quan Zhao
This study identifies fibrillarin as a repressor of the γ-globin gene and shows its dual role in activating BCL11A and repressing γ-globin expression, offering a potential therapeutic target for β-hemoglobinopathies.