David C.S. Huang

Structural and functional basis of PU.1-BAF interaction enables targeting of lineage-specific transcription

This paper identifies the structural basis of PU.1-BAF interaction and shows small molecules can disrupt it, offering a new therapeutic strategy for cancer.

Fibrillarin modulates fetal hemoglobin silencing

This study identifies fibrillarin as a repressor of the γ-globin gene and shows its dual role in activating BCL11A and repressing γ-globin expression, offering a potential therapeutic target for β-hemoglobinopathies.

Single-cell Rapid Capture Hybridization sequencing (scRaCH-seq) to reliably detect isoform usage and coding mutations in targeted genes at a single-cell level

The paper introduces scRaCH-seq, a method for single-cell long-read sequencing that improves detection of isoform usage and mutations in targeted genes, demonstrating its application in CLL samples.

Comprehensive characterization of single cell full-length isoforms in human and mouse with long-read sequencing

The paper develops FLT-seq and FLAMES to characterize full-length isoforms in single cells of human and mouse, identifying thousands of unannotated isoforms and linking them to functional modules and drug resistance mutations.

Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection

This study identifies two parallel pathways regulated by WAPL and telomere deprotection that lead to mitotic death in replication stressed human cells.