Actomyosin Contractility Drives Bile Regurgitation as an Early Homeostatic Response to Increased Biliary Pressure in Obstructive Cholestasis
Kapish Gupta, Qiushi Li, Junjun Fan, Eliza Li Shan Fong, Ziwei Song, Shupei Mo, Haoyu Tang, Inn Chuan Ng, Chan Way Ng, Pornteera Pawijit, Shuangmu Zhuo, Chen-Yuan Dong, Boon Chuan Low, Aileen Wee, Yock Young Dan, , Hanry Yu
This study identifies actomyosin contractility as a mechanism driving bile regurgitation in obstructive cholestasis by forming vesicles that relieve biliary pressure.
bioRxiv · Sep 28, 2016Cell Biology