Phenethylaminylation: Preliminary In Vitro Evidence for the Covalent Transamidation of Psychedelic Phenethylamines to Glial Proteins using 3,5-Dimethoxy-4-(2-Propynyloxy)-Phenethylamine as a Model Compound
Rajiv S. Rangan, R. Max Petty, Suchismita Acharya, Kyle A. Emmitte, Rafael do Valle, Chandra Lam, Salman I. Essajee, William Mayhew, Olivia Young, Calvin D. Brooks, Michael J. Forster, Tara Tovar-Vidales, Abbot F. Clark
The paper investigates phenethylaminylation, a potential covalent modification of glial proteins by psychedelics, using a propargylated mescaline analog and click-chemistry in astrocyte cultures.
bioRxiv · Feb 13, 2025 · PreprintMolecular Biology