Mac/Lac-tosylceramide regulates intestinal homeostasis and secretory cell fate commitment by facilitating Notch signaling
Kebei Tang, Xuewen Li, Jiulong Hu, Jingyuan Shi, Yumei Li, Yansu Chen, Chang Yin, Fengchao Wang, Rongwen Xi
This study identifies a specific glycosphingolipid metabolite that modulates Notch signaling in intestinal stem cells, affecting cell fate and tumor formation in both Drosophila and mammals.
eLife · Dec 9, 2025Peer-reviewedDevelopmental Biology