Developmental BiologyeLifePeer-reviewed
Mac/Lac-tosylceramide regulates intestinal homeostasis and secretory cell fate commitment by facilitating Notch signaling
Kebei Tang, Xuewen Li, Jiulong Hu…·Rongwen Xi
This study identifies a specific glycosphingolipid metabolite that modulates Notch signaling in intestinal stem cells, affecting cell fate and tumor formation in both Drosophila and mammals.
DOI 10.7554/elife.106184.3