Targeting redox regulatory site of protein kinase B impedes neutrophilic inflammation
Po-Jen Chen, I-Ling Ko, Chia-Lin Lee, Hao-Chun Hu, Fang-Rong Chang, Yang-Chang Wu, Yann-Lii Leu, Chih-Ching Wu, Cheng-Yu Lin, Chang-Yu Pan, Yung-Fong Tsai, Tsong-Long Hwang
This study identifies CLLV-1 as a covalent AKT inhibitor that targets Cys310 to reduce neutrophilic inflammation and acute lung injury.
bioRxiv · Apr 13, 2018 · PreprintPharmacology & Toxicology