Design of High Affinity Binders to Convex Protein Target Sites
David A. Baker, Wei Yang, Derrick R. Hicks, Agnidipta Ghosh, Tristin A. Schwartze, Brian Coventry, Inna Goreshnik, Aza Allen, Samer F. Halabiya, ChanJohng Kim, Cynthia S. Hinck, David S. Lee, Asim K. Bera, Zhe Li, Yujia Wang, , Andrew P. Hinck
This paper designs high-affinity proteins that bind to convex protein sites using geometrically matching concave scaffolds, achieving low nanomolar to picomolar affinities.
bioRxiv · May 1, 2024 · PreprintBiochemistry