Zhe Li

Design of High Affinity Binders to Convex Protein Target Sites

This paper designs high-affinity proteins that bind to convex protein sites using geometrically matching concave scaffolds, achieving low nanomolar to picomolar affinities.

The Impact of Homologous Recombination Deficiency on First-line Adjuvant Chemotherapy and First-line PARPi Maintenance Therapy in Chinese Patients with Epithelial Ovarian Cancer

This study evaluates the impact of HRD status on clinical outcomes in Chinese EOC patients undergoing first-line chemotherapy and PARPi maintenance therapy, showing improved PFS and OS in HRD-positive patients.