Tristin A. Schwartze

This paper identifies co-receptors for a parasite TGFβ antagonist, uses structural data to design cell-type-specific TGFβ modulators, and demonstrates their selective antagonistic effects.

This study investigates how BMP-9 and BMP-10 form disulfide bonds and dimers, showing that geometric strain, not cysteinylation, reduces dimerization propensity and that residue swaps can reverse this effect.

This paper designs high-affinity proteins that bind to convex protein sites using geometrically matching concave scaffolds, achieving low nanomolar to picomolar affinities.