Proteomic signature and mesenchymal stromal/stem cell-derived extracellular vesicle treatment of iPSC motor neurons from different ALS patient groups
Suzy Varderidou‐Minasian, Channa E. Jakobs, Svetlana Pasteuning-Vuhman, Annabel Timmers, Maarten A. F. Altelaar, Magdalena Joanna Lorenowicz, R. Jeroen Pasterkamp
This study identifies proteomic signatures in iPSC-derived motor neurons with ALS mutations and shows MSC-EVs can reverse proteomic changes and restore neurite growth in FUS-ALS MNs.
bioRxiv · Jul 5, 2022 · PreprintNeuroscience