R. Jeroen Pasterkamp

The paper shows that using pathology-defined cell states improves reproducibility of transcriptomic signatures in ALS snRNA-seq studies compared to conventional case-control analyses.

This study creates a transcriptomic atlas of the human ventral tegmental area, identifies cell types and their functional connectivity, and links them to psychiatric disorders and BMI.

This paper introduces a method to map human cortical vasculature at high resolution, enabling quantitative analysis of vascular networks in human brain tissue.

This paper develops a high-resolution MRI platform for live cortical organoids, revealing microstructural features and temporal changes with 20 µm resolution.

This study investigates the roles of PlexinA2, PlexinA4, and NCAM in the development of mossy fibers in the hippocampus, revealing distinct and overlapping functions in axon bundling and targeting.

This study identifies cell-type-specific DNA methylation dynamics in the human cortex across development, highlighting prenatal periods as critical for epigenomic plasticity and linking changes to neurodevelopmental disorders.

The paper identifies a cortico-cerebellar pathway that modulates ipsilateral limb movement, showing its role in initiation and coordination without affecting contralateral movement.

This study shows that Sema6A, expressed by retinal ganglion cells, is essential for delineating OFF and ON functional domains in the inner plexiform layer of the mouse retina.

This study generates a conditional knockout mouse model to investigate the physiological role of SEMA6A reverse signaling in nervous system development, revealing its importance in axon pathfinding and neuron migration.

The paper performs a multiomic analysis of ALS patients and mouse models to identify sex differences, molecular subclusters, and the MAPK pathway as a therapeutic target.

SpliPath identifies pathogenic splice-altering variants in ALS by integrating SpliceAI predictions with transcriptomics data, revealing hidden heritability in rare variant disorders.

This paper investigates the anatomical development of the cerebello-thalamic tract in embryonic mice, showing that axons invade the thalamus after E16.5 and establish synapses by E18.5.

This study identifies proteomic signatures in iPSC-derived motor neurons with ALS mutations and shows MSC-EVs can reverse proteomic changes and restore neurite growth in FUS-ALS MNs.

This study identifies molecular signatures and cellular diversity during mouse habenula development using single-cell transcriptomics and links developmental subtypes to psychiatric disease.

This study identifies C21orf2 mutations in ALS as causing cilia dysfunction and impaired sonic hedgehog signaling in motor neurons.

The paper shows macrophages transfer mitochondria to neurons to resolve inflammatory pain through CD200R and iSec1 interactions.

SIRV infers spatial RNA velocities at single-cell resolution by integrating spatial transcriptomics with scRNA-seq data, revealing spatial differentiation patterns in developing tissues.

The paper develops a pipeline to analyze whole-brain immediate early gene expression after foot-shock, revealing temporal dynamics in cellular activity across brain regions.

This study shows that systemic delivery of Ant-134, timed with BBB disruption after status epilepticus, suppresses seizures in mice with long-lasting effects.

The paper identifies functional miRNAs and their targets involved in seizure suppression in temporal lobe epilepsy using animal models and functional screens.

This study shows that inhibiting PIKFYVE kinase rescues both gain- and loss-of-function C9ORF72 disease mechanisms in mouse models of ALS/FTD.

The paper provides a high-resolution proteomic signature of human iPSC-derived neurons using mass spectrometry, revealing key proteins and signaling pathways involved in neuronal development.

This study shows TRPC3 is essential for functional heterogeneity in cerebellar Purkinje cells by affecting simple and complex spike activity and behavior related to specific modules.