Maarten A. F. Altelaar

The paper benchmarks biotin enrichment in proximity labeling proteomics, showing that higher biotinylation improves specificity while lower levels increase background noise.

The paper uses spatiotemporal proteomics to study the trafficking and localization of NLGN1 and NLGN2 to the axon initial segment, revealing distinct sorting mechanisms and functional roles.

The paper identifies the phosphoS655 APP interactome in neuronal differentiation, showing it contributes to neuritogenesis through specific protein interactions.

The paper identifies GDF15 as a negative regulator of necroptotic cell death by directly interacting with RIPK3, enhancing necroptosis in tumor cells.

This paper introduces a SILAC-TMT-RTS method to study proteome changes in T cell-cancer cell co-cultures, revealing mechanisms of differential sensitivity to T cell killing.

The paper identifies a mechanism where axonal ER couples translation and secretion of transmembrane proteins to support axonal development.

This study shows that inhibiting TBK1/IKKe-mediated RIPK1 phosphorylation increases tumor sensitivity to immune cell killing by disrupting TNF signaling.

The paper develops POTATOMap to study biosynthetic lysosomal protein trafficking in neurons, revealing domain-specific mechanisms and interactions.

This study reveals how ARID1A-mediated transcriptional rewiring drives resistance to MAPK inhibitors in melanoma by altering signalling pathways, immune interactions, and receptor dynamics, highlighting potential targets for combinatorial therapies.

This study shows that single mutations during early oncogenesis can upregulate BTN2A1, enabling Vγ9Vδ2 TCR binding, but full activation requires subsequent phosphorylation of BTN3A1.

This study identifies axonal ER tubules and P180/RRBP1 as regulators of local mRNA translation in axons, showing their role in ribosome interactions and proteome dynamics.

The paper quantifies kinase activity dynamics in response to FGF ligands and uses dynamic modeling to reveal pathway regulation and novel kinase involvement.

This study identifies PAXIP1 and STAG2 as co-regulators of the Glucocorticoid Receptor (GR) that maintain 3D genome architecture and enable stress hormone-dependent transcription.

This study identifies proteomic signatures in iPSC-derived motor neurons with ALS mutations and shows MSC-EVs can reverse proteomic changes and restore neurite growth in FUS-ALS MNs.

This study identifies MAGU-2 and MPZ-1 as C. elegans orthologs of Pals1 and PATJ, showing they form a Crumbs complex and are involved in apical domain formation.

The paper identifies BBLN-1 as a regulator of lumen morphology in C. elegans intestine and identifies its mammalian ortholog bublin, which can compensate for its loss.

This study shows that Cfap53 is essential for forming the first zygotic microtubule organizing center in zebrafish embryos, but not for later cell divisions.

The paper quantitatively maps transcriptome and proteome changes during human iPSC-derived neuron polarization, identifying extensive remodeling of gene and protein expression.

The paper uses proteomics and phosphoproteomics to study mGluR-LTD in neurons, identifying key kinases and pathways involved in synaptic plasticity.

The paper uses proteomic analysis of iPSC-derived neurons to identify early molecular changes in Rett syndrome, showing altered protein expression before symptoms appear.

The paper provides a high-resolution proteomic signature of human iPSC-derived neurons using mass spectrometry, revealing key proteins and signaling pathways involved in neuronal development.

This study shows that Tau fibrils use π-stacking by arginine side chains to alter protein interactions, attracting specific proteins linked to Alzheimer's and that Hsp90 can suppress these interactions.