ProT-Diff: A Modularized and Efficient Approach to De Novo Generation of Antimicrobial Peptide Sequences through Integration of Protein Language Model and Diffusion Model
Xue‐Fei Wang, Jing‐Ya Tang, Jing Sun, Sonam Dorje, Tian‐Qi Sun, Bo Peng, Xuwo Ji, Zhe Li, Xian‐En Zhang, Dian‐Bing Wang
ProT-Diff generates novel antimicrobial peptides using a protein language model and diffusion model, producing 34 active peptides against bacteria with low toxicity.
Advanced Science · Sep 25, 2024Peer-reviewedSynthetic Biology