Mechanistic insights into Phage SSB-activated bacterial Retron-Eco8 immunity
Chao-Guang Ji, Zhuolin Li, Xin-Yang Wei, Yuelong Li, Juntao Zhang, Xueyan Liu, Ning Jia
This study reveals the molecular mechanism of Retron-Eco8 immunity by determining cryo-EM structures of the system in inactive and activated states, showing how phage SSB triggers nuclease activation and cell death.
bioRxiv · Nov 11, 2025 · PreprintMicrobiology