Ning Jia

This study shows DRT7, a reverse transcriptase-primase, generates protein-templated DNA to provide broad-spectrum antiviral immunity through abortive infection.

This study reveals the molecular mechanism of Retron-Eco8 immunity by determining cryo-EM structures of the system in inactive and activated states, showing how phage SSB triggers nuclease activation and cell death.

The paper uses CRISPRi-seq to identify FprB as a synergistic target for gallium therapy in Pseudomonas aeruginosa, enhancing gallium's efficacy against infections.