Synthesis and Evaluation of Carmofur Analogs as Antiproliferative Agents, Inhibitors to the Main Protease (Mpro) of SARS-CoV-2, and Membrane Rupture-Inducing Agents
Tiffany Gu, Amber Lu, Xina Wang, Natalie Brahan, Lexi Xu, Leyuan Zhang, Kaitlyn Su, Kody Seow, Julia Vu, Charissa Luk, Yunseo Lee, Anirudh Raman, Joseph E. Pazzi, Edward Njoo
The paper synthesizes and evaluates carmofur analogs as antiproliferative agents, Mpro inhibitors, and membrane-rupturing agents, identifying potent derivatives with specific structural modifications.
Discover Chemistry. · Apr 7, 2025Peer-reviewedBiochemistry