Edward Njoo

This study evaluates trityl and silyl ether analogs of andrographolide in murine cancer cell lines, finding potent anticancer activity and mechanisms involving apoptosis and Wnt1/β-catenin signaling.

This study evaluates aminotriester lipids as codelivery excipients for anticancer drugs, finding that a fully saturated lipid enhances amonafide activity in colorectal cancer cells but not in other cell types.

The paper evaluates analogs of MSAB, a Wnt1/{beta}-catenin inhibitor, to determine how ester substitutions affect antiproliferative activity in cancer cell lines.

This study evaluates two vinpocetine analogs with E-ring modifications, showing dose-dependent antiproliferative activity without significant apoptosis or necrosis.

This study synthesizes and evaluates glycan analogs of proscillaridin A, finding that ketalization enhances or maintains anticancer potency in vitro.

The paper develops a high-throughput platform using catalytically active CPT1a to screen for modulators, validated with known inhibitors and a library of small molecules.

The paper synthesizes and evaluates carmofur analogs as antiproliferative agents, Mpro inhibitors, and membrane-rupturing agents, identifying potent derivatives with specific structural modifications.