Epithelial to mesenchymal transition and M2 macrophages drive aggressiveness in murine and human sarcomatoid urothelial carcinoma.
Yujiro Hayashi, Roy Elias, Eugene Douglass, Akinaru Yamamoto, Matthew Schuler, Mingxiao Feng, Ekatherina Y. Batourina, Anne E. Geller, Woonyoung Choi, Gabriela Colocho, Alyssa G. Arbuiso, Samuel Jin, Adam K. Aragaki, Charles Ruland, Stanley Rapiey, , Burles Avner Johnson
The paper develops a murine model of sarcomatoid urothelial carcinoma (SUC) and finds it shares molecular and immunological features with human SUC, suggesting its use for therapeutic research.
bioRxiv · Oct 2, 2026 · PreprintCancer Biology