CRTC, not phosphorylated CREB1, drives cAMP-induced transcription across diverse cell types
Charles H. Adelmann, Xiaoqing Liu, Allison E. Greuel, Lingjuan Huang, Judth R. Boozer, Avanthika Venkatachalam, Xunwei Wu, Eleanor Ziarnik, Jiayin Tang, Ana Clara Morellato Alcantara, Joshua P. Carreras, Suyeon Ryu, Charles Shi, Long Huynh, Tristan Vornbäumen, , David E. Fisher
The paper shows that CRTC, not phosphorylated CREB1, drives cAMP-induced transcription across multiple cell types, challenging the canonical model of CREB1 activation.
bioRxiv · Jul 28, 2026 · PreprintCell Biology