Xunwei Wu

CRTC, not phosphorylated CREB1, drives cAMP-induced transcription across diverse cell types

The paper shows that CRTC, not phosphorylated CREB1, drives cAMP-induced transcription across multiple cell types, challenging the canonical model of CREB1 activation.

Rete Ridge Topography as a Determinant of Epidermal Stem Cell Identity: Implications for Skin Aging

This study shows that the concave topography of rete ridges influences epidermal stem cell differentiation and function, with changes in topography contributing to skin aging.

UV induces common cutaneous amyloid-like melanosomal protein aggregates

The paper shows UV exposure causes misfolded melanosomal proteins to aggregate, contributing to skin pigmentation disorders and melanocyte dysfunction.

Spatiotemporally resolved transcriptomics reveals subcellular RNA kinetic landscape

This paper introduces TEMPOmap, a method to profile subcellular RNA kinetics in single cells, revealing kinetic gene clusters with distinct functional roles.