Author

Charlie Manson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:fine-mapping· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Adriano De MarinoiD· 3 shared Andrew TerpolovskyiD· 3 shared Biljana NovkovićiD· 3 shared Jon Lerga-JasoiD· 3 shared Puya G. YazdiiD· 3 shared Sandra BohniD· 3 shared Abdallah Amr MahmoudiD· 2 shared Alex OsamaiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Adriano De MarinoORCID

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3 papers

Recent·Most cited

Optimization of Multi-Ancestry Polygenic Risk Score Disease Prediction Models

Jon Lerga-Jaso, Andrew Terpolovsky, Biljana Novković, Alex Osama, Charlie Manson, Sandra Bohn, Adriano De Marino, Mark Kunitomi, Puya G. Yazdi

This paper develops and evaluates ensemble polygenic risk score models for disease prediction, showing improved accuracy and portability across diverse populations when combined with clinical features.

Scientific Reports · May 20, 2025Peer-reviewedGenetic & Genomic Medicine

Selphi: Empowering GWAS Discovery through Enhanced Genotype Imputation

Adriano De Marino, Abdallah Amr Mahmoud, Sandra Bohn, Jon Lerga-Jaso, Biljana Novković, Charlie Manson, Salvatore Loguercio, Andrew Terpolovsky, Mykyta Matushyn, Ali Torkamani, Puya G. Yazdi

Selphi improves genotype imputation accuracy, especially for rare variants, enhancing GWAS discovery and polygenic risk scores.

medRxiv · Dec 18, 2023 · PreprintGenetic & Genomic Medicine

Retracing Human Genetic Histories and Natural Selection Using Precise Local Ancestry Inference

Jon Lerga-Jaso, Biljana Novković, Deepu Unnikrishnan, Varuna Bamunusinghe, Marcelinus R. Hatorangan, Charlie Manson, Haley Pedersen, Alex Osama, Andrew Terpolovsky, Sandra Bohn, Adriano De Marino, Abdallah Amr Mahmoud, Karatuğ Ozan Bircan, Umar Khan, Manfred G. Grabherr, Puya G. Yazdi

Orchestra improves local ancestry inference, revealing admixture patterns in Latin Americans, Ashkenazi Jews, and selection signals in British populations.

bioRxiv · Sep 11, 2023 · PreprintGenomics