Mark Kunitomi

Optimization of Multi-Ancestry Polygenic Risk Score Disease Prediction Models

This paper develops and evaluates ensemble polygenic risk score models for disease prediction, showing improved accuracy and portability across diverse populations when combined with clinical features.

g.nome, A Transparent Bioinformatics Pipeline that Enables Differential Expression and Alternative Splicing Analysis by Non-Computational Biologists

Predicting Epitope Candidates for SARS-CoV-2

The paper predicts epitope candidates for SARS-CoV-2 by analyzing epitope sequences from related coronaviruses and identifying conserved and diverse antigen regions across 62k genomes.

Analysis and Forecasting of Global RT-PCR Primers for SARS-CoV-2

The paper analyzes how SARS-CoV-2 mutations affect RT-PCR primer specificity and finds a 2% monthly increase in mismatches and geographic-specific virus detection.

Antiviral adaptive immunity and tolerance in the mosquito Aedes aegyti

The paper characterizes an antiviral immunity pathway in mosquitoes that uses endogenous viral elements for long-term protection and self-nonself discrimination.

The diversity, structure and function of heritable adaptive immunity sequences in the Aedes aegypti genome

The paper characterizes the genomic structure and function of endogenous viral elements (EVEs) in the Aedes aegypti Aag2 cell line using long-read sequencing, revealing their role in antiviral immunity.